Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease
نویسندگان
چکیده
منابع مشابه
Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease.
Purpose To investigate whether the blood-brain barrier (BBB) leaks blood-circulating substances in patients with early forms of Alzheimer disease (AD), and if so, to examine the extent and pattern of leakage. Materials and Methods This study was approved by the local medical ethical committees of the Maastricht University Medical Center and Leiden University Medical Center, and written informed...
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Blood-brain barrier (BBB) regulates transport of various molecules and maintains brain homeostasis. Perturbed intracellular Ca(2+) homeostasis and BBB damage have been implicated in the pathogenesis of Alzheimer disease (AD). Although receptor for advanced glycation end products (RAGE) is known to mediate Aβ transcytosis across the BBB, molecular mechanisms underlying Aβ-RAGE interaction-induce...
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ژورنال
عنوان ژورنال: Radiology
سال: 2017
ISSN: 0033-8419,1527-1315
DOI: 10.1148/radiol.2017164043